Muscle IL1 Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization
نویسندگان
چکیده
منابع مشابه
Peripheral Mechanisms of Ischemic Myalgia
Musculoskeletal pain due to ischemia is present in a variety of clinical conditions including peripheral vascular disease (PVD), sickle cell disease (SCD), complex regional pain syndrome (CRPS), and even fibromyalgia (FM). The clinical features associated with deep tissue ischemia are unique because although the subjective description of pain is common to other forms of myalgia, patients with i...
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Acid-sensing ion channels (ASICs), which are members of the sodium-selective cation channels belonging to the epithelial sodium channel/degenerin (ENaC/DEG) family, act as membrane-bound receptors for extracellular protons as well as nonproton ligands. At least five ASIC subunits have been identified in mammalian neurons, which form both homotrimeric and heterotrimeric channels. The highly prot...
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In 1934 Sylvest published a monograph in Danish entitled " Epidemic Myalgia-Bornholm Disease " in which he described a morbid condition of the intercostal and abdominal muscles, outbreaks of which occur in sufficiently large numbers in certain localities to reach epidemic proportions. The term " epidemic myalgia " was used, on the suggestion of.the late Sir George Buchanan, in order to avoid a ...
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We have used the gill- and siphon-withdrawal reflex of Aplysia californica to explore the morphological basis of the synaptic plasticity that underlies long-term sensitization. In earlier studies (Bailey and Chen, 1983, 1988a), we described 2 classes of structural changes at identified sensory neuron synapses that occur following long-term sensitization: (1) increases in the number, size, and v...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2016
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4582-15.2016